1ln6
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1eds|1EDS]], [[1edv|1EDV]], [[1edw|1EDW]], [[1fdf|1FDF]], [[1jfp|1JFP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ln6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ln6 OCA], [http://www.ebi.ac.uk/pdbsum/1ln6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ln6 RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Landin, J.]] | [[Category: Landin, J.]] | ||
[[Category: Yeagle, P L.]] | [[Category: Yeagle, P L.]] | ||
| - | [[Category: RET]] | ||
[[Category: g-protein coupled receptor]] | [[Category: g-protein coupled receptor]] | ||
[[Category: metarhodopsin ii]] | [[Category: metarhodopsin ii]] | ||
[[Category: rhodopsin]] | [[Category: rhodopsin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:04:51 2008'' |
Revision as of 19:04, 30 March 2008
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| Ligands: | |||||||
| Related: | 1EDS, 1EDV, 1EDW, 1FDF, 1JFP
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
Overview
The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.
About this Structure
1LN6 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163
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