1lum
From Proteopedia
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|PDB= 1lum |SIZE=350|CAPTION= <scene name='initialview01'>1lum</scene> | |PDB= 1lum |SIZE=350|CAPTION= <scene name='initialview01'>1lum</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1lui|1LUI]], [[1luk|1LUK]], [[1lun|1LUN]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lum OCA], [http://www.ebi.ac.uk/pdbsum/1lum PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lum RCSB]</span> | ||
}} | }} | ||
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[[Category: Fulton, D B.]] | [[Category: Fulton, D B.]] | ||
[[Category: Mallis, R J.]] | [[Category: Mallis, R J.]] | ||
| - | [[Category: ACE]] | ||
| - | [[Category: NH2]] | ||
[[Category: cis/trans isomerization]] | [[Category: cis/trans isomerization]] | ||
[[Category: interleukin-2 tyrosine kinase]] | [[Category: interleukin-2 tyrosine kinase]] | ||
| Line 38: | Line 39: | ||
[[Category: tsk]] | [[Category: tsk]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:38 2008'' |
Revision as of 19:07, 30 March 2008
| |||||||
| Ligands: | , | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Related: | 1LUI, 1LUK, 1LUN
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures
Overview
Interleukin-2 tyrosine kinase (Itk) is a T cell-specific kinase required for a proper immune response following T cell receptor engagement. In addition to the kinase domain, Itk is composed of several noncatalytic regulatory domains, including a Src homology 2 (SH2) domain that contains a conformationally heterogeneous Pro residue. Cis-trans isomerization of a single prolyl imide bond within the SH2 domain mediates conformer-specific ligand recognition that may have functional implications in T cell signaling. To better understand the mechanism by which a proline switch regulates ligand binding, we have used NMR spectroscopy to determine two structures of Itk SH2 corresponding to the cis and trans imide bond-containing conformers. The structures indicate that the heterogeneous Pro residue acts as a hinge that modulates ligand recognition by controlling the relative orientation of protein-binding surfaces.
About this Structure
1LUM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain., Mallis RJ, Brazin KN, Fulton DB, Andreotti AH, Nat Struct Biol. 2002 Dec;9(12):900-5. PMID:12402030
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