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4hl1
From Proteopedia
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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin== | ==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin== | ||
<StructureSection load='4hl1' size='340' side='right' caption='[[4hl1]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='4hl1' size='340' side='right' caption='[[4hl1]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HL1 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4gyu|4gyu]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl2|4hl2]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4gyu|4gyu]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl2|4hl2]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hl1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [http://pdbe.org/4hl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| - | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Babnigg, J]] | [[Category: Babnigg, J]] | ||
[[Category: Jedrzejczak, R]] | [[Category: Jedrzejczak, R]] | ||
Revision as of 09:19, 5 August 2016
Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin
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Categories: Beta-lactamase | Babnigg, J | Jedrzejczak, R | Joachimiak, A | Kim, Y | Structural genomic | MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors | Mire, J | Sacchettini, J | Tesar, C | Alpha-beta-beta-alpha sandwich | Hydrolase | Hydrolase-antibiotic complex | Mcsg | Mtbi | Psi-biology | Structures of mtb proteins conferring susceptibility to known mtb inhibitor
