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4em4
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA== | ==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA== | ||
<StructureSection load='4em4' size='340' side='right' caption='[[4em4]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='4em4' size='340' side='right' caption='[[4em4]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa3 Staa3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EM4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3-OXIDANYLIDENE-3-[4-(PHENYLSULFONYL)BUTYLAMINO]PROPYL]AMINO]BUTYL]+HYDROGEN+PHOSPHATE'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3-OXIDANYLIDENE-3-[4-(PHENYLSULFONYL)BUTYLAMINO]PROPYL]AMINO]BUTYL]+HYDROGEN+PHOSPHATE'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yqz|1yqz]], [[4em3|4em3]], [[4emw|4emw]], [[4eqr|4eqr]], [[4eqs|4eqs]], [[4eqw|4eqw]], [[4eqx|4eqx]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yqz|1yqz]], [[4em3|4em3]], [[4emw|4emw]], [[4eqr|4eqr]], [[4eqs|4eqs]], [[4eqw|4eqw]], [[4eqx|4eqx]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdr, SAUSA300_0873 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367830 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdr, SAUSA300_0873 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367830 STAA3])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CoA-disulfide_reductase CoA-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.14 1.8.1.14] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CoA-disulfide_reductase CoA-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.14 1.8.1.14] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4em4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4em4 RCSB], [http://www.ebi.ac.uk/pdbsum/4em4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4em4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em4 OCA], [http://pdbe.org/4em4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4em4 RCSB], [http://www.ebi.ac.uk/pdbsum/4em4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4em4 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4em4" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: CoA-disulfide reductase]] | [[Category: CoA-disulfide reductase]] | ||
| - | [[Category: | + | [[Category: Staa3]] |
[[Category: Claiborne, A]] | [[Category: Claiborne, A]] | ||
[[Category: Edwards, J S]] | [[Category: Edwards, J S]] | ||
Revision as of 09:51, 5 August 2016
Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA
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