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4ini

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Revision as of 19:58, 5 August 2016

Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP

Structural highlights

4ini is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Related:	4inc
Gene:	HINT2 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HINT2_HUMAN] Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.^[1] ^[2]

Publication Abstract from PubMed

The histidine triad proteins (HITs) constitute a large and ubiquitous superfamily of nucleotide hydrolases. The human nucleotide binding proteins (hHints) are a distinct class of HITs noted for their acyl-AMP hydrolase and phosphoramidase activity. The first high resolution crystal structures of human Hint2 with and without bound adenosine monophosphate (AMP) are here described. The differences between hHint2 and previously known HIT-family protein structures are discussed. HIT-family enzymes have historically been divided into five classes based on their catalytic specificity: Hint, Fhit, GalT, DcpS, and Aprataxin. However, although several structures exist for enzymes in these classes, the endogenous substrates of many of these enzymes have not been identified or biochemically characterized. In order to better understand the structural relationship of the HIT enzymes, a structure-based phylogeny has been constructed that has resulted in the identification of several new putative HIT clades with potential acyl-AMP hydrolase and phosphoramidase activity. This article is protected by copyright. All rights reserved.

Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily.,Maize KM, Wagner CR, Finzel BC FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Martin J, Magnino F, Schmidt K, Piguet AC, Lee JS, Semela D, St-Pierre MV, Ziemiecki A, Cassio D, Brenner C, Thorgeirsson SS, Dufour JF. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology. 2006 Jun;130(7):2179-88. PMID:16762638 doi:10.1053/j.gastro.2006.03.024
↑ Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology. 2008 Nov;149(11):5461-9. doi: 10.1210/en.2008-0400. Epub 2008 Jul , 24. PMID:18653718 doi:10.1210/en.2008-0400
↑ Maize KM, Wagner CR, Finzel BC. Structural characterization of human histidine triad nucleotide binding protein 2 (hHint2), a member of the histidine triad (HIT) superfamily. FEBS J. 2013 May 10. doi: 10.1111/febs.12330. PMID:23659632 doi:10.1111/febs.12330

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ini"

@@ Line 1: / Line 1: @@
 ==Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP==
 <StructureSection load='4ini' size='340' side='right' caption='[[4ini]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ini]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4INI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ini]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4INI FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG5:1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE'>PG5</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4inc|4inc]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HINT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285571 Streptomyces aureorectus])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HINT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ini FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ini OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ini RCSB], [http://www.ebi.ac.uk/pdbsum/4ini PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ini FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ini OCA], [http://pdbe.org/4ini PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ini RCSB], [http://www.ebi.ac.uk/pdbsum/4ini PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ini ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 18: / Line 19: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4ini" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 25: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Streptomyces aureorectus]]
+[[Category: Human]]
 [[Category: Finzel, B C]]
 [[Category: Maize, K M]]

4ini

From Proteopedia

Revision as of 19:58, 5 August 2016

Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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