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4l8d

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Revision as of 20:29, 5 August 2016

Crystal structure of the H2Db in complex with the NP-N5D peptide

Structural highlights

4l8d is a 6 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	4huu, 4huv, 4huw, 4hux, 4hv8, 4l8b, 4l8c
Gene:	H2-D1 (LK3 transgenic mice), B2m (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Publication Abstract from PubMed

Influenza A virus-specific CD8(+) cytotoxic T lymphocytes (CTLs) provide a degree of cross-strain protection that is potentially subverted by mutation. Here we describe the sequential emergence of such variants within CTL epitopes for a persistently infected, immunocompromised infant. Further analysis in immunodeficient and wild-type mice supports the view that CTL escape variants arise frequently in influenza, accumulate with time and revert in the absence of immune pressure under MHCI-mismatched conditions. Viral fitness, the abundance of endogenous CD8(+) T cell responses and T cell receptor repertoire diversity influence the nature of these de novo mutants. Structural characterization of dominant escape variants shows how the peptide-MHCI interaction is modified to affect variant-MHCI stability. The mechanism of influenza virus escape thus looks comparable to that recognized for chronic RNA viruses like HIV and HCV, suggesting that immunocompromised patients with prolonged viral infection could have an important part in the emergence of influenza quasispecies.

Acute emergence and reversion of influenza A virus quasispecies within CD8(+) T cell antigenic peptides.,Valkenburg SA, Quinones-Parra S, Gras S, Komadina N, McVernon J, Wang Z, Halim H, Iannello P, Cole C, Laurie K, Kelso A, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K Nat Commun. 2013 Oct 30;4:2663. doi: 10.1038/ncomms3663. PMID:24173108^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Valkenburg SA, Quinones-Parra S, Gras S, Komadina N, McVernon J, Wang Z, Halim H, Iannello P, Cole C, Laurie K, Kelso A, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K. Acute emergence and reversion of influenza A virus quasispecies within CD8(+) T cell antigenic peptides. Nat Commun. 2013 Oct 30;4:2663. doi: 10.1038/ncomms3663. PMID:24173108 doi:http://dx.doi.org/10.1038/ncomms3663

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4l8d"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the H2Db in complex with the NP-N5D peptide==
 <StructureSection load='4l8d' size='340' side='right' caption='[[4l8d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4huu|4huu]], [[4huv|4huv]], [[4huw|4huw]], [[4hux|4hux]], [[4hv8|4hv8]], [[4l8b|4l8b]], [[4l8c|4l8c]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8d RCSB], [http://www.ebi.ac.uk/pdbsum/4l8d PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8d OCA], [http://pdbe.org/4l8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l8d RCSB], [http://www.ebi.ac.uk/pdbsum/4l8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8d ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 18: / Line 19: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4l8d" style="background-color:#fffaf0;"></div>
 ==See Also==

4l8d

From Proteopedia

Revision as of 20:29, 5 August 2016

Crystal structure of the H2Db in complex with the NP-N5D peptide

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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