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Pregnane X receptor
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | PXR ligand-binding pocket is flexible and allows binding to structurally and chemically distinct ligands among them the macrolide antibiotic rifampicin which is used in testing tuberculosis<ref>PMID:15705662</ref>. | + | <scene name='57/571285/Cv/2'>PXR ligand-binding pocket is flexible and allows binding to structurally and chemically distinct ligands among them the macrolide antibiotic rifampicin</scene> which is used in testing tuberculosis<ref>PMID:15705662</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 08:22, 7 August 2016
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3D structures of pregnane X receptor
Updated on 07-August-2016
References
- ↑ Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev. 2002 Oct;23(5):687-702. PMID:12372848 doi:http://dx.doi.org/10.1210/er.2001-0038
- ↑ Koutsounas I, Theocharis S, Patsouris E, Giaginis C. Pregnane X receptor (PXR) at the crossroads of human metabolism and disease. Curr Drug Metab. 2013 Mar;14(3):341-50. PMID:23237007
- ↑ Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10. PMID:15705662 doi:10.1210/me.2004-0346
