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5cs7

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'''Unreleased structure'''
 
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The entry 5cs7 is ON HOLD until Paper Publication
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==The crystal structure of wt beta2-microglobulin at room temperature==
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<StructureSection load='5cs7' size='340' side='right' caption='[[5cs7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: de Rosa, M., Mota, C.S., de Sanctis, D., Bolognesi, M., Ricagno, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cs7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS7 FirstGlance]. <br>
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Description: The crystal structure of wt beta2-microglobulin at room temperature
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yxf|2yxf]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs7 OCA], [http://pdbe.org/5cs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs7 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs7 ProSAT]</span></td></tr>
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[[Category: Mota, C.S]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bolognesi, M]]
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[[Category: Mota, C S]]
[[Category: Ricagno, S]]
[[Category: Ricagno, S]]
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[[Category: De Rosa, M]]
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[[Category: Rosa, M de]]
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[[Category: De Sanctis, D]]
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[[Category: Sanctis, D de]]
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[[Category: Bolognesi, M]]
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[[Category: Amyloidosis]]
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[[Category: Beta-2 microglobulin]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin-like]]
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[[Category: Room temperature]]

Revision as of 16:19, 10 August 2016

The crystal structure of wt beta2-microglobulin at room temperature

5cs7, resolution 2.10Å

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