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4b97
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_4b97| PDB=4b97 | SCENE= }} | ||
| - | ===Biomass sensing modules from putative Rsgi-like proteins of Clostridium thermocellum resemble family 3 carbohydrate-binding module of cellulosome=== | ||
| - | {{ABSTRACT_PUBMED_24531486}} | ||
| - | == | + | ==Biomass sensing modules from putative Rsgi-like proteins of Clostridium thermocellum resemble family 3 carbohydrate-binding module of cellulosome== |
| - | [[4b97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <StructureSection load='4b97' size='340' side='right' caption='[[4b97]], [[Resolution|resolution]] 1.28Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4b97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cloth Cloth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B97 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b96|4b96]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b97 OCA], [http://pdbe.org/4b97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b97 RCSB], [http://www.ebi.ac.uk/pdbsum/4b97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b97 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The anaerobic, thermophilic, cellulosome-producing bacterium Clostridium thermocellum relies on a variety of carbohydrate-active enzymes in order to efficiently break down complex carbohydrates into utilizable simple sugars. The regulation mechanism of the cellulosomal genes was unknown until recently, when genomic analysis revealed a set of putative operons in C. thermocellum that encode sigma(I) factors (i.e. alternative sigma factors that control specialized regulon activation) and their cognate anti-sigma(I) factor (RsgI). These putative anti-sigma(I)-factor proteins have modules that are believed to be carbohydrate sensors. Three of these modules were crystallized and their three-dimensional structures were solved. The structures show a high overall degree of sequence and structural similarity to the cellulosomal family 3 carbohydrate-binding modules (CBM3s). The structures of the three carbohydrate sensors (RsgI-CBM3s) and a reference CBM3 are compared in the context of the structural determinants for the specificity of cellulose and complex carbohydrate binding. Fine structural variations among the RsgI-CBM3s appear to result in alternative substrate preferences for each of the sensors. | ||
| - | + | Fine-structural variance of family 3 carbohydrate-binding modules as extracellular biomass-sensing components of Clostridium thermocellum anti-sigma(I) factors.,Yaniv O, Fichman G, Borovok I, Shoham Y, Bayer EA, Lamed R, Shimon LJ, Frolow F Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):522-34. doi:, 10.1107/S139900471302926X. Epub 2014 Jan 31. PMID:24531486<ref>PMID:24531486</ref> | |
| - | <ref | + | |
| - | [[Category: | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | [[Category: Bayer, E A | + | </div> |
| - | [[Category: Fichman, G | + | <div class="pdbe-citations 4b97" style="background-color:#fffaf0;"></div> |
| - | [[Category: Frolow, F | + | == References == |
| - | [[Category: Lamed, R | + | <references/> |
| - | [[Category: Shimon, L J.W | + | __TOC__ |
| - | [[Category: Yaniv, O | + | </StructureSection> |
| + | [[Category: Cloth]] | ||
| + | [[Category: Bayer, E A]] | ||
| + | [[Category: Fichman, G]] | ||
| + | [[Category: Frolow, F]] | ||
| + | [[Category: Lamed, R]] | ||
| + | [[Category: Shimon, L J.W]] | ||
| + | [[Category: Yaniv, O]] | ||
[[Category: Biomass sensoring system]] | [[Category: Biomass sensoring system]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 13:57, 11 August 2016
Biomass sensing modules from putative Rsgi-like proteins of Clostridium thermocellum resemble family 3 carbohydrate-binding module of cellulosome
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