1dth

From Proteopedia

Revision as of 13:56, 5 November 2007

METALLOPROTEASE

Overview

Matrix metalloproteinase enzymes have been implicated in degenerative, processes like tumor cell invasion, metastasis, and arthritis. Specific, metalloproteinase inhibitors have been used to block tumor cell, proliferation. We have examined the interaction of batimastat (BB-94) with, a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at, 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an, unexpected binding geometry, with the thiophene ring deeply inserted into, the primary specificity site. This unprecedented binding geometry, dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor, drugs.

About this Structure

1DTH is a Single protein structure of sequence from Crotalus atrox with ZN, CA and BAT as ligands. Active as Atrolysin C, with EC number 3.4.24.42 Structure known Active Sites: CAA, CAB, ZNA and ZNB. Full crystallographic information is available from OCA.

Reference

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:8610113

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