Phosphoribosylaminoimidazole carboxylase

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== Structural highlights ==
== Structural highlights ==
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The biological assembly of E. coli PurE is <scene name='57/571253/Cv/2'>octamer</scene>. PurE active site is located in a cleft between 3 subunits<ref>PMID:10574791</ref>.
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The biological assembly of E. coli PurE is <scene name='57/571253/Cv/2'>octamer</scene>. PurE <scene name='57/571253/Cv/3'>active site</scene> is located in a <scene name='57/571253/Cv/4'>cleft between 3 subunits</scene><ref>PMID:10574791</ref>. Water molecule shown as red sphere.
</StructureSection>
</StructureSection>

Revision as of 11:53, 24 August 2016

Structure of E. coli PurE octamer complex with 5-aminoimidazole ribonucleotide (AIR) (PDB entry 1d7a)

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3D structures of PurE

Updated on 24-August-2016

References

  1. Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Biochemistry. 1992 Jun 2;31(21):5022-32. PMID:1534690
  2. Mathews II, Kappock TJ, Stubbe J, Ealick SE. Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure. 1999 Nov 15;7(11):1395-406. PMID:10574791

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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