Single-stranded DNA-binding protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1eqq| PDB=1eqq | SIZE=350| SCENE= |right|CAPTION=SSB complex with ssDNA and UMP (stick model) [[1eqq]] }} | + | {{STRUCTURE_1eqq| PDB=1eqq | SIZE=350| SCENE= |right|CAPTION=E. coli SSB complex with ssDNA and UMP (stick model) [[1eqq]] }} |
| - | '''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities. Viral SSB proteins are monomeric | + | '''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities.<br /> |
| + | * '''Viral SSB proteins''' are monomeric.<br /> | ||
| + | * '''Eukaryotic SSB''' ('''Replication protein A''' – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD).<br /> | ||
| + | * '''Mitochondrial human SSB (HsmtSSB)''' is a homotetramer. | ||
| + | |||
| + | See also [[Single stranded binding protein]]. | ||
== 3D Structures of single-stranded DNA-binding protein == | == 3D Structures of single-stranded DNA-binding protein == | ||
Revision as of 09:46, 30 August 2016
Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities.
- Viral SSB proteins are monomeric.
- Eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD).
- Mitochondrial human SSB (HsmtSSB) is a homotetramer.
See also Single stranded binding protein.
3D Structures of single-stranded DNA-binding protein
Updated on 30-August-2016
