Defensin
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics. | + | There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics<ref>PMID:2997278</ref>. |
== Disease == | == Disease == | ||
| - | Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients. | + | Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients<ref>PMID:25265350</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:05, 1 September 2016
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3D structures of defensin
Updated on 01-September-2016
References
- ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
- ↑ Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985 Oct;76(4):1427-35. PMID:2997278 doi:http://dx.doi.org/10.1172/JCI112120
- ↑ Zhuravel OV, Gerashchenko OL, Khetsuriani MR, Soldatkina MA, Pogrebnoy PV. Expression of human beta-defensins-1-4 in thyroid cancer cells and new insight on biologic activity of hBD-2 in vitro. Exp Oncol. 2014 Sep;36(3):174-8. PMID:25265350
