Succinate-semialdehyde dehydrogenase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism. | + | '''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. |
== Disease == | == Disease == | ||
| - | SSD deficiency. | + | SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia<ref>PMID:15341910</ref>. |
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== Structural highlights == | == Structural highlights == | ||
Revision as of 09:09, 4 September 2016
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3D structures of succinate-semialdehyde dehydrogenase
Updated on 04-September-2016
References
- ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
- ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
