SUMO conjugating enzyme Ubc9
From Proteopedia
(Difference between revisions)
| Line 15: | Line 15: | ||
**[[2gjd]] – yUbc9 - yeast<br /> | **[[2gjd]] – yUbc9 - yeast<br /> | ||
**[[1a3s]] - hUbc9 - human<br /> | **[[1a3s]] - hUbc9 - human<br /> | ||
| + | **[[5f6e]] – hUbc9 (mutant)<br /> | ||
**[[1u9a]] - mUbc9 - mouse<br /> | **[[1u9a]] - mUbc9 - mouse<br /> | ||
**[[1u9b]] - mUbc9 (mutant)<br /> | **[[1u9b]] - mUbc9 (mutant)<br /> | ||
| Line 23: | Line 24: | ||
**[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br /> | **[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br /> | ||
**[[2eke]] – yUbc9+SMT3<br /> | **[[2eke]] – yUbc9+SMT3<br /> | ||
| + | **[[5jne]] – yUbc9 + SMT3 + PCNA<br /> | ||
**[[2xwu]] – hUbc9+importin13 <br /> | **[[2xwu]] – hUbc9+importin13 <br /> | ||
**[[2px9]] – hUbc9+SUMO2<br /> | **[[2px9]] – hUbc9+SUMO2<br /> | ||
**[[2pe6]] - hUbc9+SUMO1<br /> | **[[2pe6]] - hUbc9+SUMO1<br /> | ||
**[[4y1l]] – hUbc9 + RSUME<br /> | **[[4y1l]] – hUbc9 + RSUME<br /> | ||
| + | **[[5f6d]], [[5f6u]], [[5f6v]], [[5f6w]], [[5f6x]], [[5f6y]] – hUbc9 (mutant) + inhibitor<br /> | ||
**[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br /> | **[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br /> | ||
**[[2grn]] - hUbc9+ RAN GTPase activating protein 1 C-terminal<br /> | **[[2grn]] - hUbc9+ RAN GTPase activating protein 1 C-terminal<br /> | ||
**[[1kps]] - hUbc9+ RAN GTPase activating protein 1 <br /> | **[[1kps]] - hUbc9+ RAN GTPase activating protein 1 <br /> | ||
**[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br /> | **[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br /> | ||
| - | **[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + | + | **[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + RANBP2<br /> |
| + | **[[4w5v]] - hUbc9+ SUMO activating enzyme <br /> | ||
| + | **[[5d2m]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + ZNF451<br /> | ||
**[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br /> | **[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br /> | ||
**[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br /> | **[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br /> | ||
Revision as of 09:54, 5 September 2016
Contents |
Function
SUMO conjugating enzyme Ubc9 accepts the ubiquitin-like SUMOs and catalyzes their attachment to other proteins with the help of E3 ligase[1].
Relevance
Ubc9 inhibitors may be therapeutic agents against fibrotic diseases like rheumatoid arthritis[2][3].
3D Structures of SUMO conjugating enzyme Ubc9
Updated on 05-September-2016
References
- ↑ Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A. Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013, May 2. PMID:23644018 doi:http://dx.doi.org/10.1016/j.molcel.2013.03.027
- ↑ Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH. Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub, 2012 Aug 17. PMID:22904261 doi:http://dx.doi.org/10.1136/annrheumdis-2012-201746
- ↑ Li F, Li X, Kou L, Li Y, Meng F, Ma F. SUMO-conjugating enzyme UBC9 promotes proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2014 Aug;37(4):1134-41. doi: 10.1007/s10753-014-9837-x. PMID:24531852 doi:http://dx.doi.org/10.1007/s10753-014-9837-x
