Sulfurtransferase

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<StructureSection load='4jgt' size='350' side='right' caption='Human mercaptopyruvate sulfurtransferase with mercaptocysteine complex with pyruvate, sulfate and glycerol (PDB entry [[4jgt]])' scene=''>
<StructureSection load='4jgt' size='350' side='right' caption='Human mercaptopyruvate sulfurtransferase with mercaptocysteine complex with pyruvate, sulfate and glycerol (PDB entry [[4jgt]])' scene=''>
== Function ==
== Function ==
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*'''Thiosulfate ST''' (TST) catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate<ref>PMID:27270587</ref>.<br />
*'''Thiosulfate ST''' (TST) catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate<ref>PMID:27270587</ref>.<br />
*'''Mercaptopyruvate ST''' (MST) transfers sulfate from mercaptopyruvate<ref>PMID:10951223</ref>.<br />
*'''Mercaptopyruvate ST''' (MST) transfers sulfate from mercaptopyruvate<ref>PMID:10951223</ref>.<br />
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== Relevance ==
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Inhibitors of MST suppress H<sub>2</sub>S production and this make non sulfur bacteria like ''E. coli'' and ''Bacillus anthracis'' sensitive to antibiotics<ref>PMID:22096201</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 06:50, 6 September 2016

Human mercaptopyruvate sulfurtransferase with mercaptocysteine complex with pyruvate, sulfate and glycerol (PDB entry 4jgt)

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3D Structures of sulfurtransferase

Updated on 06-September-2016

References

  1. ↑ Papenbrock J, Guretzki S, Henne M. Latest news about the sulfurtransferase protein family of higher plants. Amino Acids. 2011 Jun;41(1):43-57. doi: 10.1007/s00726-010-0478-6. Epub 2010 Feb , 5. PMID:20135153 doi:http://dx.doi.org/10.1007/s00726-010-0478-6
  2. ↑ Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipila P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. PMID:27270587 doi:http://dx.doi.org/10.1038/nm.4115
  3. ↑ Nakamura T, Yamaguchi Y, Sano H. Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. Eur J Biochem. 2000 Sep;267(17):5621-30. PMID:10951223
  4. ↑ Shatalin K, Shatalina E, Mironov A, Nudler E. H2S: a universal defense against antibiotics in bacteria. Science. 2011 Nov 18;334(6058):986-90. doi: 10.1126/science.1209855. PMID:22096201 doi:http://dx.doi.org/10.1126/science.1209855
  5. ↑ Yadav PK, Yamada K, Chiku T, Koutmos M, Banerjee R. Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. J Biol Chem. 2013 May 22. PMID:23698001 doi:10.1074/jbc.M113.466177

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