|
|
| (12 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | [[Image:2b2s.gif|left|200px]]<br /><applet load="2b2s" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[5sx0]] This PDB entry is obsolete and replaced by 5sx0 |
| - | caption="2b2s, resolution 2.00Å" />
| + | |
| - | '''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH7.5'''<br />
| + | |
| - | | + | |
| - | ==Overview==
| + | |
| - | The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 2B2S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=O:'>O</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2S OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16211084 16211084]
| + | |
| - | [[Category: Burkholderia pseudomallei]]
| + | |
| - | [[Category: Catalase]]
| + | |
| - | [[Category: Single protein]]
| + | |
| - | [[Category: Carpena, X.]]
| + | |
| - | [[Category: Deemagarn, T.]]
| + | |
| - | [[Category: Fita, I.]]
| + | |
| - | [[Category: Ivancich, A.]]
| + | |
| - | [[Category: Loewen, P.C.]]
| + | |
| - | [[Category: Singh, R.]]
| + | |
| - | [[Category: Switala, J.]]
| + | |
| - | [[Category: Wiseman, B.]]
| + | |
| - | [[Category: HEM]]
| + | |
| - | [[Category: NA]]
| + | |
| - | [[Category: O]]
| + | |
| - | [[Category: catalase-peroxidase]]
| + | |
| - | [[Category: compound i]]
| + | |
| - | [[Category: katg]]
| + | |
| - | [[Category: oxoferryl species]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:15:12 2008''
| + | |
