This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5eir
From Proteopedia
(Difference between revisions)
m (Protected "5eir" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.== | |
| - | + | <StructureSection load='5eir' size='340' side='right' caption='[[5eir]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eir]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O8:~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-AZANYL-6-OXIDANYLIDENE-7-(PHENYLMETHYL)-1~{H}-PURIN-7-IUM-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>5O8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v8w|2v8w]], [[2w97|2w97]]</td></tr> |
| - | [[Category: Nowicki, M | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eir OCA], [http://pdbe.org/5eir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eir RCSB], [http://www.ebi.ac.uk/pdbsum/5eir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eir ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fischer, P M]] | ||
| + | [[Category: Nowicki, M W]] | ||
| + | [[Category: Walkinshaw, M D]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Eif4e]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Translation]] | ||
Revision as of 21:04, 10 September 2016
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
| |||||||||||
