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5gj6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens== | |
| - | + | <StructureSection load='5gj6' size='340' side='right' caption='[[5gj6]], [[Resolution|resolution]] 2.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gj6]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GJ6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gj6 OCA], [http://pdbe.org/5gj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5gj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gj6 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9Q2P6_9REOV Q9Q2P6_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Duan, Z]] | ||
| + | [[Category: Sun, X]] | ||
| + | [[Category: Rotavirus]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 21:05, 10 September 2016
Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens
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