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5j6x
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the apo-Zalpha of Zebrafish PKZ== | |
| + | <StructureSection load='5j6x' size='340' side='right' caption='[[5j6x]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5j6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6X FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6x OCA], [http://pdbe.org/5j6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6x RCSB], [http://www.ebi.ac.uk/pdbsum/5j6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j6x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Z-DNA-binding domain of PKZ from zebrafish (Danio rerio; drZalphaPKZ ) contains the largest beta-wing among known Z-DNA-binding domains. To elucidate the functional implication of the beta-wing, we solved the crystal structure of apo-drZalphaPKZ . Structural comparison with its Z-DNA-bound form revealed a large conformational change within the beta-wing during Z-DNA binding. Biochemical studies of protein mutants revealed that two basic residues in the beta-wing are responsible for Z-DNA recognition as well as fast B-Z transition. Therefore, the extra basic residues in the beta-wing of drZalphaPKZ are necessary for the fast B-Z transition activity. | ||
| - | + | Structural and functional studies of a large winged Z-DNA-binding domain of Danio rerio protein kinase PKZ.,Subramani VK, Kim D, Yun K, Kim KK FEBS Lett. 2016 Jul;590(14):2275-85. doi: 10.1002/1873-3468.12238. Epub 2016 Jun , 23. PMID:27265117<ref>PMID:27265117</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5j6x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kim, D]] | ||
| + | [[Category: Kim, K K]] | ||
| + | [[Category: Subramani, V K]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Pkz zdna zalpha whth]] | ||
Revision as of 21:08, 10 September 2016
Crystal structure of the apo-Zalpha of Zebrafish PKZ
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