Thiolase

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**[[2wu9]], [[2c7y]], [[2c7z]] – KCT peroxisomal residues 36-462 – ''Arabidopsis thaliana''<br />
**[[2wu9]], [[2c7y]], [[2c7z]] – KCT peroxisomal residues 36-462 – ''Arabidopsis thaliana''<br />
**[[2wua]] - KCT peroxisomal residues 17-449 (mutant) – sunflower<br />
**[[2wua]] - KCT peroxisomal residues 17-449 (mutant) – sunflower<br />
-
**[[2iik]] – hKCT peroxisomal - human<br />
+
**[[2iik]] – hKCT peroxisomal – human<br />
**[[4c2k]] – hKCT mitochondrial <br />
**[[4c2k]] – hKCT mitochondrial <br />
**[[4c2j]] – hKCT mitochondrial + CoA<br />
**[[4c2j]] – hKCT mitochondrial + CoA<br />
**[[3goa]] – KCT – ''Salmonella typhimurium''<br />
**[[3goa]] – KCT – ''Salmonella typhimurium''<br />
-
**[[1afw]], [[1pxt]] – yKCT peroxisomal - yeast<br />
+
**[[5lp7]] – KCT – ''Bacillus subtilis'' <br />
 +
**[[1afw]], [[1pxt]] – yKCT peroxisomal – yeast<br />
 +
**[[5cbq]] – MsKCT – ''Mycobacterium smegmatis'' <br />
 +
**[[4w61]] – ReKCT – ''Ralstonia eutropha''<br />
 +
**[[4ubw]] – MtKCT – ''Mycobacterium tuberculosis'' <br />
 +
 
 +
*3-ketoacyl-CoA thiolase complex
 +
 
**[[3w15]] - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor<br />
**[[3w15]] - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor<br />
**[[2d3t]] – PfKCT + fatty oxidation complex β subunit – ''Pseudomonas fragi''<br />
**[[2d3t]] – PfKCT + fatty oxidation complex β subunit – ''Pseudomonas fragi''<br />
-
**[[1wdk]], [[1wdl]], [[1wdm]] - PfKCT + fatty oxidation complex α subunit
+
**[[1wdk]], [[1wdl]], [[1wdm]] - PfKCT + fatty oxidation complex α subunit<br />
 +
**[[5bz4]] – MsKCT + CoA <br />
 +
**[[4ubt]] – MtKCT (mutant) + CoA + steroid <br />
 +
**[[4ubu]] – MtKCT (mutant) + CoA <br />
 +
**[[4ubv]] – MtKCT + CoA + acetyl CoA <br />
*Acetoacetyl-CoA thiolase
*Acetoacetyl-CoA thiolase
**[[1m4s]], [[1m4t]], [[1dlu]], [[1qfl]] - ZrACT – ''Zoogloea ramigera''<br />
**[[1m4s]], [[1m4t]], [[1dlu]], [[1qfl]] - ZrACT – ''Zoogloea ramigera''<br />
-
**[[1dm3]], [[1dlv]] – ZrACT + CoA<br />
+
**[[2wku]], [[ 2wl6]], [[1m1t]], [[1m3k]] - ZrACT (mutant) <br />
-
**[[2wku]], [[2wl6]], [[1m1t]], [[1m3k]] - ZrACT (mutant) <br />
+
**[[2ib7]], [[ 2ib8]], [[2ib9]], [[2ibu]], [[2ibw]], [[2iby]], [[2f2s]] – hACT mitochondrial<br />
-
**[[2wkt]], [[2wkv]], [[2wl4]], [[2wl5]], [[2vtz]], [[2vu0]], [[1m3z]] – ZrACT (mutant) + CoA<br />
+
**[[1wl5]] - hACT cytosolic<br />
 +
**[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br />
 +
**[[4xl2]], [[4xl3]], [[4n44]], [[4n45]] – CaACT – ''Clostridium acetobutylicum''<br />
 +
**[[4wyr]] – CaACT (mutant) <br />
 +
**[[5f0v]], [[ [[5f38]], [[4wys]] – ACT – ''Escherichia coli'' <br />
 +
**[[4o9a]], [[4o99]], [[4o9c]], [[4nzs]] – ReACT <br />
 +
 
 +
*Acetoacetyl-CoA thiolase complex
 +
 
 +
**[[1dm3]], [[1dlv – ZrACT + CoA<br />
 +
**[[2wkt]], [[2wkv]], [[2wl4]], [[2wl5]], [[2vtz]], [[1m3z]] – ZrACT (mutant) + CoA<br />
**[[1m1o]] - ZrACT (mutant) + acetoacetyl-CoA<br />
**[[1m1o]] - ZrACT (mutant) + acetoacetyl-CoA<br />
**[[2vu0]], [[1nl7]] - ZrACT + CoA<br />
**[[2vu0]], [[1nl7]] - ZrACT + CoA<br />
**[[2vu1]], [[2vu2]], [[1ou6]] - ZrACT + pantheteine-11-pivalate<br />
**[[2vu1]], [[2vu2]], [[1ou6]] - ZrACT + pantheteine-11-pivalate<br />
-
**[[2ib7]], [[2ib8]], [[2ib9]], [[2ibu]], [[2ibw]], [[2iby]], [[2f2s]] – hACT mitochondrial<br />
+
**]]1wl4]] – hACT cytosolic + CoA <br />
-
**[[1wl5]] - hACT cytosolic<br />
+
**[[4xl4]] – CaACT + CoA <br />
-
**[[1wl4]] – hACT cytosolic + CoA<br />
+
 
-
**[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br />
+
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:33, 12 September 2016

Human 3-ketoacyl-CoA complex with CoA and ethylene glycol(PDB code 4c2j).

Drag the structure with the mouse to rotate

3D Structures of Thiolase

Updated on 12-September-2016

References

  1. ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
  2. ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287
  3. ↑ Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi:, 10.1107/S1399004714023827. Epub 2014 Nov 22. PMID:25478839 doi:http://dx.doi.org/10.1107/S1399004714023827

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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