Thioredoxin Glutathione Reductase
From Proteopedia
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| - | <StructureSection load='2x8c' size=' | + | <StructureSection load='2x8c' size='450' side='right' scene='' caption='Thioredoxin glutathione reductase with cofactor FAD dimer complex with triethylene glycol [[2x8c]]'> |
== Function == | == Function == | ||
[[Thioredoxin Glutathione Reductase]] (TGR) is an enzyme which bridges two detoxification pathways<ref>PMID:21782895</ref>. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal. | [[Thioredoxin Glutathione Reductase]] (TGR) is an enzyme which bridges two detoxification pathways<ref>PMID:21782895</ref>. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal. | ||
Revision as of 11:44, 13 September 2016
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3D Structures of Thioredoxin Glutathione Reductase
2v6o, 2x8c, 2x8g, 2x8h – SmTGR+FAD – Schistosoma mansoni
2x99 - SmTGR+FAD+NADPH
3h4k - SmTGR+FAD+auranofin
4la1 - TGR+FAD – Schistosoma japonicum
References
- ↑ Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec;1810(12):1262-71. doi:, 10.1016/j.bbagen.2011.06.024. Epub 2011 Jul 14. PMID:21782895 doi:http://dx.doi.org/10.1016/j.bbagen.2011.06.024
- ↑ Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS One. 2012;7(2):e31456. doi: 10.1371/journal.pone.0031456. Epub 2012 Feb 22. PMID:22384025 doi:http://dx.doi.org/10.1371/journal.pone.0031456
- ↑ Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography. J Biol Chem. 2010 Jul 21. PMID:20659890 doi:10.1074/jbc.M110.141960
