Thioredoxin Glutathione Reductase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The active site of TGR contains | + | The active site of TGR contains <scene name='43/433645/Cv/4'>CXXXXC motif and FAD</scene><ref>PMID:20659890</ref>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Thioredoxin Glutathione Reductase == | == 3D Structures of Thioredoxin Glutathione Reductase == | ||
Revision as of 12:39, 13 September 2016
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3D Structures of Thioredoxin Glutathione Reductase
2v6o, 2x8c, 2x8g, 2x8h – SmTGR+FAD – Schistosoma mansoni
2x99 - SmTGR+FAD+NADPH
3h4k - SmTGR+FAD+auranofin
4la1 - TGR+FAD – Schistosoma japonicum
References
- ↑ Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec;1810(12):1262-71. doi:, 10.1016/j.bbagen.2011.06.024. Epub 2011 Jul 14. PMID:21782895 doi:http://dx.doi.org/10.1016/j.bbagen.2011.06.024
- ↑ Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS One. 2012;7(2):e31456. doi: 10.1371/journal.pone.0031456. Epub 2012 Feb 22. PMID:22384025 doi:http://dx.doi.org/10.1371/journal.pone.0031456
- ↑ Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography. J Biol Chem. 2010 Jul 21. PMID:20659890 doi:10.1074/jbc.M110.141960
