4z2c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Quinolone(Moxifloxacin)-DNA cleavage complex of gyrase from S. pneumoniae== | |
| - | + | <StructureSection load='4z2c' size='340' side='right' caption='[[4z2c]], [[Resolution|resolution]] 3.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z2c]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr> |
| - | [[Category: Fisher, L | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> |
| - | [[Category: Pan, X | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2c OCA], [http://pdbe.org/4z2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2c RCSB], [http://www.ebi.ac.uk/pdbsum/4z2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2c ProSAT]</span></td></tr> |
| - | [[Category: Sanderson, M | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Crevel, I M.T]] | ||
| + | [[Category: Fisher, L M]] | ||
| + | [[Category: Laponogov, I]] | ||
| + | [[Category: Pan, X S]] | ||
| + | [[Category: Sanderson, M R]] | ||
[[Category: Selvarajah, J]] | [[Category: Selvarajah, J]] | ||
| - | [[Category: Veselkov, D | + | [[Category: Veselkov, D A]] |
| - | [[Category: | + | [[Category: Cleavage complex]] |
| - | [[Category: | + | [[Category: Dna]] |
| + | [[Category: Gyrase]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Quinolone]] | ||
Revision as of 15:25, 14 September 2016
Quinolone(Moxifloxacin)-DNA cleavage complex of gyrase from S. pneumoniae
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Categories: Crevel, I M.T | Fisher, L M | Laponogov, I | Pan, X S | Sanderson, M R | Selvarajah, J | Veselkov, D A | Cleavage complex | Dna | Gyrase | Isomerase | Quinolone
