4z2e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Quinolone(Trovafloxacin)-DNA cleavage complex of gyrase from S. pneumoniae== | |
| - | + | <StructureSection load='4z2e' size='340' side='right' caption='[[4z2e]], [[Resolution|resolution]] 3.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z2e]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TR6:TROVAFLOXACIN'>TR6</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr> |
| - | [[Category: Fisher, L | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> |
| - | [[Category: Pan, X | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2e OCA], [http://pdbe.org/4z2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2e RCSB], [http://www.ebi.ac.uk/pdbsum/4z2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2e ProSAT]</span></td></tr> |
| - | [[Category: Sanderson, M | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9R867_STREE Q9R867_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] [[http://www.uniprot.org/uniprot/Q59957_STREE Q59957_STREE]] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01898] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Crevel, I M.T]] | ||
| + | [[Category: Fisher, L M]] | ||
| + | [[Category: Laponogov, I]] | ||
| + | [[Category: Pan, X S]] | ||
| + | [[Category: Sanderson, M R]] | ||
[[Category: Selvarajah, J]] | [[Category: Selvarajah, J]] | ||
| - | [[Category: Veselkov, D | + | [[Category: Veselkov, D A]] |
| - | [[Category: | + | [[Category: Cleavage complex]] |
| - | [[Category: | + | [[Category: Dna]] |
| + | [[Category: Gyrase]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Quinolone]] | ||
Revision as of 15:25, 14 September 2016
Quinolone(Trovafloxacin)-DNA cleavage complex of gyrase from S. pneumoniae
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Categories: Crevel, I M.T | Fisher, L M | Laponogov, I | Pan, X S | Sanderson, M R | Selvarajah, J | Veselkov, D A | Cleavage complex | Dna | Gyrase | Isomerase | Quinolone
