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5de4

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'''Unreleased structure'''
 
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The entry 5de4 is ON HOLD until Paper Publication
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==Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC==
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<StructureSection load='5de4' size='340' side='right' caption='[[5de4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5de4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DE4 FirstGlance]. <br>
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Description: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5DZ:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5DZ</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ddn|5ddn]], [[5ddx|5ddx]], [[5dex|5dex]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5de4 OCA], [http://pdbe.org/5de4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5de4 RCSB], [http://www.ebi.ac.uk/pdbsum/5de4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5de4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Conti, P]]
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[[Category: Hansen, K B]]
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[[Category: Mou, T C]]
[[Category: Pinto, A]]
[[Category: Pinto, A]]
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[[Category: Sprang, S R]]
[[Category: Tamborini, L]]
[[Category: Tamborini, L]]
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[[Category: Conti, P]]
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[[Category: Antagonist]]
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[[Category: Hansen, K.B]]
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[[Category: Nmda receptor]]
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[[Category: Sprang, S.R]]
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[[Category: Receptor]]
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[[Category: Mou, T.-C]]
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[[Category: Transport protein]]

Revision as of 15:28, 14 September 2016

Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC

5de4, resolution 2.40Å

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