This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5dhp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor== | |
| - | + | <StructureSection load='5dhp' size='340' side='right' caption='[[5dhp]], [[Resolution|resolution]] 2.27Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dhp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AQ:8-({2-OXO-2-[(2-PHENYLETHYL)AMINO]ETHYL}SULFANYL)ADENOSINE'>5AQ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhu|5dhu]], [[5dht|5dht]], [[5dhs|5dhs]], [[5dhr|5dhr]], [[5dhq|5dhq]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhp OCA], [http://pdbe.org/5dhp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhp RCSB], [http://www.ebi.ac.uk/pdbsum/5dhp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Assairi, L]] | ||
| + | [[Category: Gelin, M]] | ||
[[Category: Huteau, V]] | [[Category: Huteau, V]] | ||
[[Category: Labesse, G]] | [[Category: Labesse, G]] | ||
| - | [[Category: | + | [[Category: Paoletti, J]] |
[[Category: Pochet, S]] | [[Category: Pochet, S]] | ||
| - | [[Category: | + | [[Category: Tetrameric nad kinase]] |
| - | [[Category: | + | [[Category: Transferase]] |
Revision as of 15:28, 14 September 2016
Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor
| |||||||||||
