Tryptase inhibitor
From Proteopedia
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<StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (aqua) complex with trypsin (dark green) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''> | <StructureSection load='1ldt' size='400' side='right' caption='Structure of leech tryptase inhibitor (aqua) complex with trypsin (dark green) and Ca+2 ion (green) (PDB entry [[1ldt]])' scene=''> | ||
| - | '''Tryptase inhibitors''' (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations. | + | '''Tryptase inhibitors''' (TI) are protein inhibitors of tryptase belonging to the group of Kazal-type inhibitors and exhibiting a distinctive disulfide pattern<ref>PMID:9242660</ref>. |
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| + | == Relevance == | ||
| + | TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations. | ||
</StructureSection> | </StructureSection> | ||
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**[[2lfk]], [[2lfl]] – tTI - NMR | **[[2lfk]], [[2lfl]] – tTI - NMR | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 08:06, 27 September 2016
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3D structures of tryptase inhibitor
Updated on 27-September-2016
References
- ↑ Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA. The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. J Biol Chem. 1997 Aug 8;272(32):19931-7. PMID:9242660
