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5ad3

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'''Unreleased structure'''
 
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The entry 5ad3 is ON HOLD until Paper Publication
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==Bivalent binding to BET bromodomains==
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<StructureSection load='5ad3' size='340' side='right' caption='[[5ad3]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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Authors: Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., Dale, I., Daniels, D., Flavell, L., Holdgate, G., Jowitt, T.A., Kikhney, A., McAlister, M., Ogg, D., Patel, J., Petteruti, P., Robb, G.R., Robers, M., Stratton, N., Svergun, D.I., Wang, W., Whittaker, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD3 FirstGlance]. <br>
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Description: Bivalent binding to BET bromodomains
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ad2|5ad2]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [http://pdbe.org/5ad3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bobby, R]]
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[[Category: Boiko, S]]
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[[Category: Bradbury, R H]]
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[[Category: Callis, R]]
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[[Category: Chen, H]]
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[[Category: Dale, I]]
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[[Category: Daniels, D]]
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[[Category: Flavell, L]]
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[[Category: Holdgate, G]]
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[[Category: Jowitt, T A]]
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[[Category: Kikhney, A]]
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[[Category: McAlister, M]]
[[Category: Ogg, D]]
[[Category: Ogg, D]]
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[[Category: Patel, J]]
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[[Category: Petteruti, P]]
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[[Category: Rabow, A A]]
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[[Category: Robb, G R]]
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[[Category: Robers, M]]
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[[Category: Stratton, N]]
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[[Category: Svergun, D I]]
[[Category: Walker, G]]
[[Category: Walker, G]]
[[Category: Wang, W]]
[[Category: Wang, W]]
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[[Category: Rabow, A.A]]
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[[Category: Waring, M J]]
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[[Category: Stratton, N]]
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[[Category: Robers, M]]
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[[Category: Petteruti, P]]
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[[Category: Dale, I]]
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[[Category: Chen, H]]
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[[Category: Robb, G.R]]
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[[Category: Jowitt, T.A]]
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[[Category: Waring, M.J]]
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[[Category: Callis, R]]
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[[Category: Whittaker, D]]
[[Category: Whittaker, D]]
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[[Category: Svergun, D.I]]
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[[Category: Transcription]]
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[[Category: Flavell, L]]
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[[Category: Patel, J]]
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[[Category: Mcalister, M]]
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[[Category: Bobby, R]]
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[[Category: Kikhney, A]]
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[[Category: Holdgate, G]]
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[[Category: Bradbury, R.H]]
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[[Category: Boiko, S]]
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[[Category: Daniels, D]]
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Revision as of 17:00, 3 October 2016

Bivalent binding to BET bromodomains

5ad3, resolution 1.49Å

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