5aod
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of wild type pneumolysin.== | |
| - | + | <StructureSection load='5aod' size='340' side='right' caption='[[5aod]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aod]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aoe|5aoe]], [[5aof|5aof]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [http://pdbe.org/5aod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [http://www.ebi.ac.uk/pdbsum/5aod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pee, K van]] | ||
[[Category: Yildiz, O]] | [[Category: Yildiz, O]] | ||
| - | [[Category: | + | [[Category: Cholesterol dependent cytolysin]] |
| + | [[Category: Pore forming toxin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 21:19, 5 October 2016
Crystal structure of wild type pneumolysin.
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