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4dt0

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Revision as of 07:16, 18 October 2016

The structure of the peripheral stalk subunit E from Pyrococcus horikoshii

Structural highlights

4dt0 is a 1 chain structure with sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2dm9, 2dma
Gene:	atpE, PH1978 (Pyrococcus horikoshii)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VATE_PYRHO] Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).

Publication Abstract from PubMed

A(1)A(O) ATP synthases are the major energy converters of archaea. They are composed of an A(1) region that synthesizes ATP and an integral part A(O) that conducts ions. Subunit E is a component of the peripheral stalk that links the A(1) with the A(O) part of the A-ATP synthase. We have determined the crystal structure of the entire subunit E (PhE) of the Pyrococcus horikoshii OT3 A-ATP synthase at 3.6 A resolution. The structure reveals an extended S-shaped N-terminal alpha-helix with 112.29 A in length, followed by a globular head group. The S-shaped feature, common in elastic connectors and spacers, would facilitate the storage of transient elastic energy during rotary motion in the enzyme. The structure has been superimposed into the asymmetric peripheral stalks of the three-dimensional reconstruction of the Pyrococcus furiosus enzyme, revealing that the S-shaped subunit PhE fits well into the bent peripheral stalk, whereas the previously solved E subunit structure (3.1 A resolution) of Thermus thermophilus A-ATP synthase is well accommodated in the density of the straight stator domain. The different features of the two stalk subunits are discussed in light of a novel coupling mechanism in A-ATP synthases proposed to differ from the Wankel engine of F-ATP synthases.

The Structure of Subunit E of the Pyrococcus horikoshii OT3 A-ATP Synthase Gives Insight into the Elasticity of the Peripheral Stalk.,Balakrishna AM, Hunke C, Gruber G J Mol Biol. 2012 Apr 16. PMID:22516614^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Balakrishna AM, Hunke C, Gruber G. The Structure of Subunit E of the Pyrococcus horikoshii OT3 A-ATP Synthase Gives Insight into the Elasticity of the Peripheral Stalk. J Mol Biol. 2012 Apr 16. PMID:22516614 doi:10.1016/j.jmb.2012.04.012

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4dt0"

@@ Line 3: / Line 3: @@
 <StructureSection load='4dt0' size='340' side='right' caption='[[4dt0]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4dt0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrho Pyrho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DT0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4dt0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DT0 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2dm9|2dm9]], [[2dma|2dma]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atpE, PH1978 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 PYRHO])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atpE, PH1978 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dt0 OCA], [http://pdbe.org/4dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dt0 ProSAT]</span></td></tr>
 </table>
@@ Line 26: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Pyrho]]
+[[Category: Pyrococcus horikoshii]]
 [[Category: Balakrishna, A M]]
 [[Category: Gruber, G]]

4dt0

From Proteopedia

Revision as of 07:16, 18 October 2016

The structure of the peripheral stalk subunit E from Pyrococcus horikoshii

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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