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5hob
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==p73 homo-tetramerization domain mutant I== | |
| - | + | <StructureSection load='5hob' size='340' side='right' caption='[[5hob]], [[Resolution|resolution]] 1.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hob]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HOB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kby|2kby]], [[4a9z|4a9z]], [[5hoc|5hoc]], [[2nb1|2nb1]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hob OCA], [http://pdbe.org/5hob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hob RCSB], [http://www.ebi.ac.uk/pdbsum/5hob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hob ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Coutandin, D]] | ||
| + | [[Category: Dotsch, V]] | ||
| + | [[Category: Knapp, S]] | ||
| + | [[Category: Krojer, T]] | ||
| + | [[Category: Mathea, S]] | ||
| + | [[Category: Salah, E]] | ||
| + | [[Category: Hetero-tetramerization]] | ||
| + | [[Category: Homo-tetramerization mutant]] | ||
| + | [[Category: P73]] | ||
| + | [[Category: Tetramerization domain]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 00:58, 20 October 2016
p73 homo-tetramerization domain mutant I
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