5syn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349== | |
| - | + | <StructureSection load='5syn' size='340' side='right' caption='[[5syn]], [[Resolution|resolution]] 1.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5syn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SYN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71T:2-[4-(4-METHOXYPHENYL)PIPERAZINE-1-CARBONYL]-5LAMBDA~6~-THIENO[3,2-C][1]BENZOTHIOPYRAN-5,5(4H)-DIONE'>71T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5sym|5sym]]</td></tr> |
| - | [[Category: Labby, K | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5syn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5syn OCA], [http://pdbe.org/5syn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5syn RCSB], [http://www.ebi.ac.uk/pdbsum/5syn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5syn ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Meagher, J | + | == Function == |
| - | [[Category: Stuckey, J | + | [[http://www.uniprot.org/uniprot/LYPA2_HUMAN LYPA2_HUMAN]] May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.<ref>PMID:21152083</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Labby, K J]] | ||
| + | [[Category: Martin, B R]] | ||
| + | [[Category: Meagher, J L]] | ||
| + | [[Category: Stuckey, J A]] | ||
| + | [[Category: Won, S J]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Thioesterase]] | ||
Revision as of 18:50, 26 October 2016
Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349
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