6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
From Proteopedia
(Difference between revisions)
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**[[3hd1]], [[3hsg]], [[3ht0]], [[3ilj]], [[3kuh]] – EcHPPK (mutant) + methyleneadenosine-triphosphate <br /> | **[[3hd1]], [[3hsg]], [[3ht0]], [[3ilj]], [[3kuh]] – EcHPPK (mutant) + methyleneadenosine-triphosphate <br /> | ||
**[[3ud5]], [[3ude]], [[3udv]], [[4f7v]] – EcHPPK + inhibitor <br /> | **[[3ud5]], [[3ude]], [[3udv]], [[4f7v]] – EcHPPK + inhibitor <br /> | ||
| - | **[[3qbc]] – | + | **[[4pzv]] - HPPK/DHPS + inhibitor - ''Francisella tularensis''<br /> |
| + | **[[3qbc]] – SaHPPK + inhibitor – ''Staphylococcus aureus''<br /> | ||
*HPPK ternary complex | *HPPK ternary complex | ||
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**[[4m5g]], [[4m5h]], [[4m5i]], [[4m5j]], [[4m5k]], [[4m5l]], [[4m5m]], [[4m5n]] – EcHPPK + methyleneadenosine-triphosphate + inhibitor <br /> | **[[4m5g]], [[4m5h]], [[4m5i]], [[4m5j]], [[4m5k]], [[4m5l]], [[4m5m]], [[4m5n]] – EcHPPK + methyleneadenosine-triphosphate + inhibitor <br /> | ||
**[[1rao]] – EcHPPK (mutant) + AMP + 6-hydroxymethylpterin-diphosphate <br /> | **[[1rao]] – EcHPPK (mutant) + AMP + 6-hydroxymethylpterin-diphosphate <br /> | ||
| + | **[[5etl]], [[5etm]], [[5etn]], [[5eto]], [[5etp]], [[5etq]], [[5etr]], [[5ets]], [[5ett]], [[5etv]] - EcHPPK + AMPCPP + inhibitor<br /> | ||
| + | **[[4crj]], [[4cwb]], [[4cyu]] - SaHPPK + AMPCPP + inhibitor<br /> | ||
**[[2qx0]] – HPPK + methyleneadenosine-triphosphate + pteridine derivative – ''Yersinia pestis''<br /> | **[[2qx0]] – HPPK + methyleneadenosine-triphosphate + pteridine derivative – ''Yersinia pestis''<br /> | ||
Revision as of 19:49, 31 October 2016
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3D structures of HPPK
Updated on 31-October-2016
References
- ↑ Xiao B, Shi G, Chen X, Yan H, Ji X. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Structure. 1999 May;7(5):489-96. PMID:10378268
