Elizeu/sandbox/citocromo c

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<Structure load='1chc' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><Structure load='4riu' size='350' frame='true' align='right' caption='4RIU' scene='Insert optional scene name here' />
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This is my image
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==Description/Function==
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<Structure load='RibavirinJMU.png' size='350' frame='true' align='right' caption='Ribavirin' scene='Insert optional scene name here' />
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The Ring finger motif of BRCA1 is located near the N-terminus (residues 24 - 64). The Ring finger motif does not form a stable structure by itself. Rather it is a part of larger domains comprising residues 1-109 of BRCA1. The first 100 residues, including the Ring finger motif, are the most highly conserved regions among known BRCA1 genes. It is also a zinc-binding motif, conserved pattern of cysteine and histidine residues
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==Abbreviations==
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RING-really interesting new gene; BRCA1- Breast Cancer 1 gene;
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==Ligands==
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E3 Ubiquitin Ligase
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==Focal Points==
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Many cancers are made exceedingly invasive when tumors are subjected to hypoxic stresses triggered by a decrease of oxygen in the tumor’s microenvironment or by aspects involved with inflammation. Hypoxic stress increases tumor growth, metastasis, invasiveness and resistance to treatments. When under hypoxic stress the pH of the tumor’s microenvironment decreases while the pH inside the tumor stays fairly normal and when this differential environment is altered it is fatal to the tumor cells. Carbonic anhydrase IX influences the differential pH and when it is inhibited it decreases tumor growth and enhances the effectiveness of cancer treatments. Saccharin binds to CA IX with nano molar affinity and preferential binding thus inhibiting CA IX.
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The SAC has a preference in binding to CA IX and CA XII over CA I and II. This is believed to be due to the substitution of PHE131 for Val in CA IX. It binds directly to the catalytic zinc of the CA IX-mimic displacing the zinc-bound OH-/H2O.
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==Critical Amino Acids==
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<scene name='55/559112/Leu_91/1'>Leu 91</scene>
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<scene name='55/559112/Leu_198/1'>Leu 198</scene>
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<scene name='55/559112/Val_131/2'>Val 131</scene>
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==References==
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Brian P. Mahon, Alex M. Hendon, Jenna M. Driscoll, Gregory M. Rankin, Sally-Ann Poulsen, Claudiu T. Supuran, Robert McKenna, Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors, Bioorganic & Medicinal Chemistry, Volume 23, Issue 4, 15 February 2015, Pages 849-854, ISSN 0968-0896, http://dx.doi.org/10.1016/j.bmc.2014.12.030.
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(http://www.sciencedirect.com/science/article/pii/S0968089614008785)
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====Authors====
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Elizabeth A. Dunlap, Preeti K. Deol
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Revision as of 02:54, 15 November 2016

This is my image

Ribavirin

Drag the structure with the mouse to rotate
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