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Ferritin

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Line 26: Line 26:
**[[2jd8]] – PfFR+Zn<br />
**[[2jd8]] – PfFR+Zn<br />
**[[3kxu]] – hFR (mutant) – human<br />
**[[3kxu]] – hFR (mutant) – human<br />
-
**[[3hx2]], [[3hx5]], [[3hx7]], [[1fha]] - hFR<br />
+
**[[4v6b]], [[1fha]] - hFR<br />
**[[3a68]] – soFR from gene SferH4 – soybean<br />
**[[3a68]] – soFR from gene SferH4 – soybean<br />
**[[3a9q]] - soFR from gene SferH4 (mutant) <br />
**[[3a9q]] - soFR from gene SferH4 (mutant) <br />

Revision as of 07:58, 17 November 2016

Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus, 2jd7

Drag the structure with the mouse to rotate

Contents

Function

Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).[1] Amphibians have an additional middle subunit FR (FTM).

  • Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.
  • Thioferritin (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.
  • Another iron storing protein is the DNA-binding Protein of Starved cells (Dps) - a ferritin-like diiron carboxylate.
  • MrgA – another iron storage protein - belongs to the Dps family.

Relevance

Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder.

Disease

FR deficiency can lead to anemia.

3D Structures of Ferritin

Updated on 17-November-2016

References

  1. ↑ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, David Canner, Eran Hodis, Alexander Berchansky

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