Galactosidase

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<StructureSection load='1kwk' size='450' side='right' caption='Beta-galactosidase complex with galactose, MPD, acetate Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[1kwk]])' scene='45/458439/Cv/2'>
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<StructureSection load='1kwk' size='350' side='right' caption='Beta-galactosidase complex with galactose, MPD, acetate Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[1kwk]])' scene='45/458439/Cv/2'>
== Function ==
== Function ==
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**[[3og2]] – TrBgal – ''Trichoderma reesei''<br />
**[[3og2]] – TrBgal – ''Trichoderma reesei''<br />
**[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br />
**[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br />
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**[[1hn1]], [[1dp0]], [[1f49]], [[1f4a]], [[1f4h]], [[1gho]], [[1bgl]], [[1bgm]], [[4ttg]] - EcBgal<br />
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**[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br />
**[[3j7h]] – EcBgal – cryo EM<br />
**[[3j7h]] – EcBgal – cryo EM<br />
**[[3dec]], [[3d3a]], [[3bga]] – BtBgal<br />
**[[3dec]], [[3d3a]], [[3bga]] – BtBgal<br />
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**[[4ean]] – SsBgal + indole<br />
**[[4ean]] – SsBgal + indole<br />
**[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br />
**[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br />
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**[[3mv0]], [[3i3b]], [[3czj]], [[1jz0]], [[1jz1]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br />
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**[[3mv0]], [[3i3b]], [[3czj]], [[4v45]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br />
**[[3mv1]] - EcBgal (mutant) + guanidinium<br />
**[[3mv1]] - EcBgal (mutant) + guanidinium<br />
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**[[1jyn]], [[1jyy]], [[1jyz]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br />
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**[[1jyn]], [[4v44]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br />
**[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br />
**[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br />
**[[1jz6]] - EcBgal (mutant) + inhibitor<br />
**[[1jz6]] - EcBgal (mutant) + inhibitor<br />

Revision as of 09:01, 17 November 2016

Beta-galactosidase complex with galactose, MPD, acetate Ca+2 (green) and Zn+2 (grey) ions (PDB entry 1kwk)

Drag the structure with the mouse to rotate

3D Structures of Galactosidase

Updated on 17-November-2016

References

  1. ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
  2. ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
  3. ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
  4. ↑ Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
  5. ↑ Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416


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