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Ubiquitin
From Proteopedia
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<StructureSection load='3k9p' size='340' side='right' caption='Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (grey), [[3k9p]]' scene='' > | <StructureSection load='3k9p' size='340' side='right' caption='Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (grey), [[3k9p]]' scene='' > | ||
| - | + | -- Function == | |
| - | + | [[Ubiquitin]] (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome<ref>PMID:9759494</ref>. For details see<br /> | |
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| - | [[Ubiquitin]] (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. At least 4 UBB molecules are needed to tag a protein for the proteasome. For details see<br /> | + | |
* [[Ubiquitin Structure & Function]]<br /> | * [[Ubiquitin Structure & Function]]<br /> | ||
* [[Ubiquitin salt bridge discussion]]<br /> | * [[Ubiquitin salt bridge discussion]]<br /> | ||
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==Additional Resources== | ==Additional Resources== | ||
See: [[Ubiquitin Structure & Function]] for additional information. | See: [[Ubiquitin Structure & Function]] for additional information. | ||
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| + | == Disease == | ||
| + | The UBB-proteasome system deregulation has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson disease, Huntington disease, Prion-like lethal disorders and in genetic diseases like cystic fibrosis, angelman's syndrome, Liddle syndrome and many cancers<ref>PMID:18937370</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Ubiquitin == | == 3D Structures of Ubiquitin == | ||
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**[[3n32]] – hUBB+Pt<br /> | **[[3n32]] – hUBB+Pt<br /> | ||
}} | }} | ||
| + | ==References== | ||
| + | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:56, 29 November 2016
Image:1d3z.png
NMR Structure of Ubiquitin, 1d3z
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3D Structures of Ubiquitin
Updated on 29-November-2016
References
- ↑ Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem. 1998;67:425-79. PMID:9759494 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.425
- ↑ Paul S. Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches. Bioessays. 2008 Nov;30(11-12):1172-84. doi: 10.1002/bies.20852. PMID:18937370 doi:http://dx.doi.org/10.1002/bies.20852
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