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5eql

From Proteopedia

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m (Protected "5eql" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5eql is ON HOLD until Paper Publication
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==Isoform-specific inhibition of SUMO-dependent protein-protein interactions==
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<StructureSection load='5eql' size='340' side='right' caption='[[5eql]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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Authors: Hughes, D.J., Tiede, C., Hall, N., Tang, A.A.S., Trinh, C.H., Zajac, K., Mandal, U., Howell, G., Edwards, T.A., McPherson, M.J., Tomlinson, D.C., Whitehouse, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5eql]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQL FirstGlance]. <br>
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Description: Isoform-specific inhibition of SUMO-dependent protein-protein interactions
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eql OCA], [http://pdbe.org/5eql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eql RCSB], [http://www.ebi.ac.uk/pdbsum/5eql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eql ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Whitehouse, A]]
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== Function ==
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[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Edwards, T A]]
[[Category: Hall, N]]
[[Category: Hall, N]]
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[[Category: Trinh, C.H]]
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[[Category: Howell, G]]
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[[Category: Tomlinson, D.C]]
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[[Category: Hughes, D J]]
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[[Category: Tang, A.A.S]]
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[[Category: Mandal, U]]
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[[Category: Edwards, T.A]]
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[[Category: McPherson, M J]]
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[[Category: Mcpherson, M.J]]
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[[Category: Tang, A A.S]]
[[Category: Tiede, C]]
[[Category: Tiede, C]]
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[[Category: Howell, G]]
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[[Category: Tomlinson, D C]]
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[[Category: Trinh, C H]]
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[[Category: Whitehouse, A]]
[[Category: Zajac, K]]
[[Category: Zajac, K]]
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[[Category: Hughes, D.J]]
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[[Category: Protein binding]]
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[[Category: Mandal, U]]
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[[Category: Sumoylation]]
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[[Category: Ubiquitin]]

Revision as of 10:48, 10 December 2016

Isoform-specific inhibition of SUMO-dependent protein-protein interactions

5eql, resolution 2.49Å

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