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5fnc
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Dynamic Undocking and the Quasi-Bound State as tools for Drug Design== | |
| - | + | <StructureSection load='5fnc' size='340' side='right' caption='[[5fnc]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fnc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IEE:6-CHLORO-4-N-[(4-METHYLPHENYL)METHYL]PYRIMIDINE-+2,4-DIAMINE'>IEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fnd|5fnd]], [[5fnf|5fnf]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnc OCA], [http://pdbe.org/5fnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnc RCSB], [http://www.ebi.ac.uk/pdbsum/5fnc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baker, L M]] | ||
| + | [[Category: Barril, X]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
| + | [[Category: Hubbard, R]] | ||
| + | [[Category: Luque, F J]] | ||
| + | [[Category: Matassova, N]] | ||
[[Category: Murray, J]] | [[Category: Murray, J]] | ||
| + | [[Category: Roughley, S]] | ||
[[Category: Ruiz-Carmona, S]] | [[Category: Ruiz-Carmona, S]] | ||
| - | [[Category: Hubbard, R]] | ||
| - | [[Category: Barril, X]] | ||
| - | [[Category: Matassova, N]] | ||
[[Category: Schmidtke, P]] | [[Category: Schmidtke, P]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Drug design]] |
| - | [[Category: | + | [[Category: Hsp90]] |
| + | [[Category: Oncology]] | ||
Revision as of 10:50, 10 December 2016
Dynamic Undocking and the Quasi-Bound State as tools for Drug Design
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Categories: Baker, L M | Barril, X | Davis, B | Hubbard, R | Luque, F J | Matassova, N | Murray, J | Roughley, S | Ruiz-Carmona, S | Schmidtke, P | Chaperone | Drug design | Hsp90 | Oncology
