This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5j41
From Proteopedia
(Difference between revisions)
m (Protected "5j41" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Glutathione S-transferase bound with hydrolyzed Piperlongumine== | |
| - | + | <StructureSection load='5j41' size='340' side='right' caption='[[5j41]], [[Resolution|resolution]] 1.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j41]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J41 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3LF:3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC+ACID'>3LF</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j41 OCA], [http://pdbe.org/5j41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j41 RCSB], [http://www.ebi.ac.uk/pdbsum/5j41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j41 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glutathione transferase]] | ||
| + | [[Category: Ficarro, S]] | ||
| + | [[Category: Gondi, S]] | ||
[[Category: Gurbani, D]] | [[Category: Gurbani, D]] | ||
| + | [[Category: Harshbarger, W]] | ||
[[Category: Hunter, J]] | [[Category: Hunter, J]] | ||
| - | [[Category: Harshbarger, W]] | ||
| - | [[Category: Westover, K]] | ||
[[Category: Marto, J]] | [[Category: Marto, J]] | ||
| - | [[Category: Ficarro, S]] | ||
| - | [[Category: Gondi, S]] | ||
[[Category: Udayakumar, D]] | [[Category: Udayakumar, D]] | ||
| + | [[Category: Westover, K]] | ||
| + | [[Category: Glutathione]] | ||
| + | [[Category: Gstp1]] | ||
| + | [[Category: Piperlongumine]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 18:34, 10 December 2016
Glutathione S-transferase bound with hydrolyzed Piperlongumine
| |||||||||||
