This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5tc1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2== | |
| - | + | <StructureSection load='5tc1' size='340' side='right' caption='[[5tc1]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tc1]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2] and [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TC1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ms2|2ms2]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc1 OCA], [http://pdbe.org/5tc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc1 ProSAT]</span></td></tr> |
| - | [[Category: Dai, X | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2]] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref> [[http://www.uniprot.org/uniprot/MAT_BPMS2 MAT_BPMS2]] The maturation protein is required for the typical attachment of the phage to the side of the bacterial pili (PubMed:23810697). MP binds to sequences located toward each end of the genome, hence circularizing it (PubMed:26608810). The RNA genome-MP complex is released from the capsid upon host receptor binding (PubMed:23810697). MP enters the cell along with the viral RNA (PubMed:4551992).<ref>PMID:23810697</ref> <ref>PMID:26608810</ref> <ref>PMID:4551992</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Enterobacteria phage ms2]] | ||
| + | [[Category: Enterobacterio phage ms2]] | ||
| + | [[Category: Dai, X H]] | ||
| + | [[Category: Du, Y S]] | ||
| + | [[Category: Lai, M]] | ||
| + | [[Category: Li, Z H]] | ||
[[Category: Shu, S]] | [[Category: Shu, S]] | ||
| - | [[Category: Lai, M]] | ||
| - | [[Category: Zhou, Z.H]] | ||
| - | [[Category: Du, Y.S]] | ||
| - | [[Category: Li, Z.H]] | ||
[[Category: Sun, R]] | [[Category: Sun, R]] | ||
| + | [[Category: Zhou, Z H]] | ||
| + | [[Category: Asymmetric cryoem reconstruction]] | ||
| + | [[Category: Genome-capsid interaction]] | ||
| + | [[Category: Genome-delivery apparatus]] | ||
| + | [[Category: Ssrna genome structure]] | ||
| + | [[Category: Viral protein-rna complex]] | ||
Revision as of 02:19, 11 December 2016
In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2
| |||||||||||
