Uridylate kinase

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== Structural highlights ==
== Structural highlights ==
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The active site of UK has high specificity to uracil and excludes purine nucleotides<ref>PMID:17297917</ref>.
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The biological assembly of Uridylate kinase from ''Sulfolobus solfataricus'' ([[2j4k]]) is <scene name='48/487531/Cv/2'>homohexamer</scene>. The active site of UK has high specificity to uracil and excludes purine nucleotides<ref>PMID:17297917</ref>.
</StructureSection>
</StructureSection>
==3D structures of uridylate kinase==
==3D structures of uridylate kinase==

Revision as of 08:35, 14 December 2016

Uridylate kinase hexamer complex with ligand UMP (stick model), Cd+ (gold) and Mg+2 (green) ions 2j4k

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3D structures of uridylate kinase

Updated on 14-December-2016

References

  1. Yan H, Tsai MD. Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity. Adv Enzymol Relat Areas Mol Biol. 1999;73:103-34, x. PMID:10218107
  2. Jensen KS, Johansson E, Jensen KF. Structural and enzymatic investigation of the Sulfolobus solfataricus uridylate kinase shows competitive UTP inhibition and the lack of GTP stimulation. Biochemistry. 2007 Mar 13;46(10):2745-57. Epub 2007 Feb 13. PMID:17297917 doi:10.1021/bi0618159

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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