Lysine-specific histone demethylase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 51: Line 51:
**[[4gu0]] – hLSD2 + histone 3.3 peptide <br />
**[[4gu0]] – hLSD2 + histone 3.3 peptide <br />
-
*lysine-specific histone demethylase 5B
+
*lysine-specific demethylase 4A or JMJD2A
 +
 
 +
**[[5fyh]], [[5fyc]], [[5fyi]] – hLSD4A<br />
 +
**[[5fy8]] – hLSD4A + threo-isocitrate<br />
 +
**[[5f2s]], [[5f2w]]. [[5f32]], [[5f37]], [[5f39]], [[5f3c]], [[5f3e]], [[5f3g]], [[5f3i]], [[5fpv]] – hLSD4A + inhibitor<br />
 +
 
 +
*lysine-specific demethylase 4D or KDM4D
 +
 
 +
**[[5fp7]], [[5fp4]], [[5fp8]], [[5fp9]], [[5fpa]], [[5fpb]], [[5f5c]], [[5f5i]], [[5f5a]] – hLSD4D + inhibitor<br />
 +
 
 +
*lysine-specific demethylase 5A or KDM5A or JARID1A
 +
 
 +
**[[5k4l]], [[5ceh]] – hLSD5A + inhibitor + peptide<br />
 +
**[[5c11]] – hLSD5A PHD finger + histone peptide<br />
 +
**[[5isl]], [[5ivc]], [[5ive]], [[5ivf]], [[5ivj]], [[5ivv]], [[5ivy]], [[5iw0]], [[5iwf]] – hLSD5A Jmj domain + inhibitor <br />
 +
**[[5ivb]], [[5e6h]] – hLSD5A Jmj domain + a-ketoglutarate<br />
 +
**[[2kgg]] – hLSD5A PHD finger - NMR<br />
 +
**[[2kgi]] – hLSD5A PHD finger + histone peptide - NMR<br />
 +
**[[3gl6]] – hLSD5A PHD finger + histone peptide <br />
 +
**[[2jxj]] – hLSD5A ARID domain - NMR<br />
 +
 
 +
*lysine-specific histone demethylase 5B or JARID1B or KDM5B
**[[2ma5]] – hLSD5B zinc finger domain 3 - NMR<br />
**[[2ma5]] – hLSD5B zinc finger domain 3 - NMR<br />
**[[2mny]] – hLSD5B zinc finger domain 1 - NMR<br />
**[[2mny]] – hLSD5B zinc finger domain 1 - NMR<br />
**[[2mnz]] – hLSD5B zinc finger domain 1 + histone 3 peptide - NMR<br />
**[[2mnz]] – hLSD5B zinc finger domain 1 + histone 3 peptide - NMR<br />
 +
**[[2eqy]] – hLSD5B ARID domain - NMR<br />
 +
**[[5a3p]] – hLSD5B Jmj domain <br />
 +
**[[5lwb]], [[5lw9]], [[5fun]], [[5fz0]], [[5fzk]], [[5fzl]], [[5fz9]], [[5fza]], [[5fzb]], [[5fzc]], [[5fyt]], [[5fyu]], [[5fyy]], [[5fyz]], [[5fz3]], [[5fz4]], [[5fz6]], [[5fz7]], [[5fpl]], [[5fpu]], [[5a3n]], [[5a3t]], [[5a3w]] – hLSD5B Jmj domain + inhibitor<br />
 +
**[[5fzh]], [[5fz1]] – hLSD5B Jmj domain + ligand<br />
 +
**[[5fup]] – hLSD5B + oxoglutarate<br />
 +
**[[5fv3]], [[5a1f]] – hLSD5B + oxalyl glycine<br />
 +
 +
*lysine-specific demethylase 5C or JARID1C or KDM5C
 +
 +
**[[5fwj]] – hLSD5C Jmj domain + inhibitor<br />
 +
**[[2jrz]] – hLSD5C Bright/ARID domain - NMR<br />
 +
 +
*lysine-specific demethylase 5D or JARID1D
 +
 +
**[[2yqe]] – hLSD5D ARID domain - NMR<br />
 +
 +
*lysine-specific demethylase 6B or JMJD3
 +
 +
**[[5fp3]] – hLSD6B Jmj domain + inhibitor<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:31, 28 December 2016

Human FAD-containing LSD1 (cyan) complex with CoREST (green) and histone H3 helix (deeppink), 2v1d

Drag the structure with the mouse to rotate

3D structures of lysine-specific histone demethylase 1

Updated on 28-December-2016

References

  1. ↑ Chen Y, Jie W, Yan W, Zhou K, Xiao Y. Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr. 2012;22(1):53-9. PMID:22339659
  2. ↑ Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May, 10. PMID:22533360 doi:http://dx.doi.org/10.1021/cb300108c
  3. ↑ van Essen D, Zhu Y, Saccani S. A feed-forward circuit controlling inducible NF-kappaB target gene activation by promoter histone demethylation. Mol Cell. 2010 Sep 10;39(5):750-60. doi: 10.1016/j.molcel.2010.08.010. PMID:20832726 doi:http://dx.doi.org/10.1016/j.molcel.2010.08.010
  4. ↑ Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7096-101. doi:, 10.1073/pnas.1324036111. Epub 2014 Apr 28. PMID:24778210 doi:http://dx.doi.org/10.1073/pnas.1324036111
  5. ↑ Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Lysine-specific_histone_demethylase"
Personal tools