Retinoid isomerohydrolase
From Proteopedia
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| - | <StructureSection load='4rsc' size=' | + | <StructureSection load='4rsc' size='450' side='right' caption='Bovine RPE65 complex with palmitate, amixustat and Fe+2 ion (PDB code [[4rsc]])' scene='74/749418/Cv/1'> |
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== Structural highlights == | == Structural highlights == | ||
| - | The inhibitor RPE65 drug amixutat binds in the active site near the enzyme's membrane-embedded substrate -entry point. The catalytic Fe+2 is 5-coordinated<ref>PMID:25894083</ref>. | + | The inhibitor RPE65 drug amixutat binds in the active site near the enzyme's membrane-embedded substrate-entry point. The catalytic Fe+2 is 5-coordinated<ref>PMID:25894083</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 09:22, 8 January 2017
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3D structures of resolvase
Updated on 08-January-2017
4f2z, 4f30, 4f3a, 4f3d, 3kvc, 3fsn – bRPE65 - bovine
4ryx, 4ryy, 4ryz, 4rsc – bRPE65 + emixustat
4zhk, 4rse – bRPE65 + MB-200
References
- ↑ Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 3;281(5):2835-40. Epub 2005 Nov 30. PMID:16319067 doi:http://dx.doi.org/10.1074/jbc.M508903200
- ↑ Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun, 15. PMID:26075817 doi:http://dx.doi.org/10.1172/JCI80950
- ↑ Cai X, Conley SM, Naash MI. RPE65: role in the visual cycle, human retinal disease, and gene therapy. Ophthalmic Genet. 2009 Jun;30(2):57-62. doi: 10.1080/13816810802626399. PMID:19373675 doi:http://dx.doi.org/10.1080/13816810802626399
- ↑ Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr, 20. PMID:25894083 doi:http://dx.doi.org/10.1038/nchembio.1799
