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From Proteopedia
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= Trichosurin : a Possum Milk Whey Lipocalin Protein = | = Trichosurin : a Possum Milk Whey Lipocalin Protein = | ||
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| - | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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| - | == Description == | ||
Trichosurin is one of the three predominant lipocalins found in the milk of the brushtail possum ''Trichosurus vulpecula''. | Trichosurin is one of the three predominant lipocalins found in the milk of the brushtail possum ''Trichosurus vulpecula''. | ||
The lipocalins are a large family of proteins that diverse in sequence but are structurally homologous. They bind and transport small hydrophobic molecules in a central hydrophobic pocket. The lipocalin family is defined by a common fold : an eight-stranded anti-parallel β-barrel with variable loop regions flanking and enclosing the top and bottom of the barrel, to form a hydrophobic pocket. | The lipocalins are a large family of proteins that diverse in sequence but are structurally homologous. They bind and transport small hydrophobic molecules in a central hydrophobic pocket. The lipocalin family is defined by a common fold : an eight-stranded anti-parallel β-barrel with variable loop regions flanking and enclosing the top and bottom of the barrel, to form a hydrophobic pocket. | ||
| + | |||
| + | |||
| + | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| + | the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Fonction == | == Fonction == | ||
| - | In the lipocalin family, the internal topology of the hydrophobic pocket is a key factor to understand the type and | + | In the lipocalin family, the internal topology of the hydrophobic pocket is a key factor to understand the type and the selectivity of binding. In fact, the access to the binding pocket is controlled by residues forming a loop between the β-strands at one end of the lipocalin β-barrel. |
Thus, the function of trichosurin is critical in metatherian lactation. But for the moment, the biochemical and biological functions of the trichosurin are not understood. | Thus, the function of trichosurin is critical in metatherian lactation. But for the moment, the biochemical and biological functions of the trichosurin are not understood. | ||
Revision as of 09:13, 22 January 2017
Trichosurin : a Possum Milk Whey Lipocalin Protein
Trichosurin is one of the three predominant lipocalins found in the milk of the brushtail possum Trichosurus vulpecula. The lipocalins are a large family of proteins that diverse in sequence but are structurally homologous. They bind and transport small hydrophobic molecules in a central hydrophobic pocket. The lipocalin family is defined by a common fold : an eight-stranded anti-parallel β-barrel with variable loop regions flanking and enclosing the top and bottom of the barrel, to form a hydrophobic pocket.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
