Thiaminase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='4thi' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Thiaminase''' (Thi) cleaves vitamin B1. '''Thiaminase I''' cataly...) |
|||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1yak' size='340' side='right' caption='Thiaminase II complex with pyrimidine derivative' scene=''> | |
| - | <StructureSection load=' | + | |
| Line 7: | Line 6: | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | The active site of thiaminase II contains a pyrimidine derivative. Three residues participate in the substrate binding and the pyrimidine ring is sandwiched between two tyrosine residues<ref>PMID:15709744</ref>. | |
</StructureSection> | </StructureSection> | ||
| Line 19: | Line 18: | ||
**[[4hcw]] – amThia I – amoeba <br /> | **[[4hcw]] – amThia I – amoeba <br /> | ||
**[[4hcy]] – amThia I + deazathiamin <br /> | **[[4hcy]] – amThia I + deazathiamin <br /> | ||
| - | **[[2thi]], [[3thi]] – BtThia I – Bacillus thiaminolyticus <br /> | + | **[[2thi]], [[3thi]] – BtThia I – ''Bacillus thiaminolyticus'' <br /> |
**[[4thi]] – BtThia I + pyrimidine derivative <br /> | **[[4thi]] – BtThia I + pyrimidine derivative <br /> | ||
* Thiaminase II | * Thiaminase II | ||
| - | **[[4fn6]] – Thia II – Staphylococcus aureus <br /> | + | **[[4fn6]] – Thia II – ''Staphylococcus aureus'' <br /> |
| - | **[[3no6]] – Thia II – Staphylococcus epidermidis <br /> | + | **[[3no6]] – Thia II – ''Staphylococcus epidermidis'' <br /> |
| - | **[[1yaf]] – BsThia II – Bacillus subtilis <br /> | + | **[[1yaf]] – BsThia II – ''Bacillus subtilis'' <br /> |
**[[1yak]] – BsThia II + pyrimidine derivative <br /> | **[[1yak]] – BsThia II + pyrimidine derivative <br /> | ||
**[[2qcx]] – BsThia II (mutant) + pyrimidine derivative <br /> | **[[2qcx]] – BsThia II (mutant) + pyrimidine derivative <br /> | ||
Revision as of 09:32, 25 January 2017
| |||||||||||
3D Structures of thiaminase
Updated on 25-January-2017
References
- ↑ Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D. Structure of a eukaryotic thiaminase I. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110., Epub 2013 Dec 18. PMID:24351929 doi:http://dx.doi.org/10.1073/pnas.1315882110
- ↑ Onozuka M, Konno H, Kawasaki Y, Akaji K, Nosaka K. Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae. FEMS Yeast Res. 2008 Mar;8(2):266-75. Epub 2007 Nov 19. PMID:18028398 doi:http://dx.doi.org/10.1111/j.1567-1364.2007.00333.x
- ↑ Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. PMID:15709744 doi:http://dx.doi.org/10.1021/bi0478648
