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Cell division protein

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== Function ==
== Function ==
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'''Cell Division Protein FtsZ''' (Ftsz) is the prokaryotic homolog of tubulin. Ftsz assembles into a ring at the site of the septum in bacterial cell division. Ftsz stands for Filamenting Temperature-Sensitive mutant Z. Ftsz can bind GTP and hydrolyze it to GDP.<ref>PMID:15558053</ref>
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'''Cell Division Protein FtsZ''' (Ftsz) is the prokaryotic homolog of tubulin. Ftsz assembles into a ring at the site of the septum in bacterial cell division. Ftsz stands for Filamenting Temperature-Sensitive mutant Z. Ftsz can bind GTP and hydrolyze it to GDP<ref>PMID:15558053</ref>. ZapA, ZapB, ZapC (Z-Associated Protein) are regulators which modulate the dynamics of the FtsZ ring at midcell division site<ref>PMID:21216995</ref>.
== Structural highlights ==
== Structural highlights ==
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**[[1f47]] – EcFtsz + EcZipa – ''Escherichia coli''<br />
**[[1f47]] – EcFtsz + EcZipa – ''Escherichia coli''<br />
**[[4m8i]] - Ftsz + GDP – ''Staphylococcus epidermidis''<br />
**[[4m8i]] - Ftsz + GDP – ''Staphylococcus epidermidis''<br />
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*ZapA
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**[[2mmv]] – ZapA – ''Geobacillus stearothermophilus'' - NMR <br />
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**[[4p1m]] - EcZapA <br />
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**[[1w2e]] - PaZapA <br />
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*ZapB
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**[[2jee]] - EcZapB <br />
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*ZapC
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**[[5e1l]], [[5fo3]] - EcZapC <br />
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}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:47, 25 January 2017

Ftsz complex with GTP (PDB code 1w5b)

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3D Structures of cell division protein Ftsz

Updated on 25-January-2017

References

  1. ↑ Oliva MA, Cordell SC, Lowe J. Structural insights into FtsZ protofilament formation. Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:15558053 doi:10.1038/nsmb855
  2. ↑ Durand-Heredia JM, Yu HH, De Carlo S, Lesser CF, Janakiraman A. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J Bacteriol. 2011 Mar;193(6):1405-13. doi: 10.1128/JB.01258-10. Epub 2011 Jan 7. PMID:21216995 doi:http://dx.doi.org/10.1128/JB.01258-10
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