Elizeu/sandbox/citocromo c
From Proteopedia
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== Overview == | == Overview == | ||
| - | PsaA is a multi-functional lipoprotein detected on all known serotypes of ''Streptococcus pneumoniae''. This lipoprotein belongs to the ABC-type transport protein complex that transports Mn2+. PsaA is also an adhesion factor that plays a major role in pneumococcal attachment to the host cell and virulence. So, PsaA protein is involved in in colonization of the nasopharyngeal mucosal. | + | PsaA (Pneumococcal surface antigen A) is a multi-functional lipoprotein detected on all known serotypes of ''Streptococcus pneumoniae''. This lipoprotein belongs to the ABC-type transport protein complex that transports Mn2+. ABC means ATP binding complex. PsaA is also an adhesion factor that plays a major role in pneumococcal attachment to the host cell and virulence. So, PsaA protein is involved in in colonization of the nasopharyngeal mucosal. |
[[Image:PsaA dans ABC transporteur.jpg]] | [[Image:PsaA dans ABC transporteur.jpg]] | ||
Revision as of 14:22, 25 January 2017
Contents |
Overview
PsaA (Pneumococcal surface antigen A) is a multi-functional lipoprotein detected on all known serotypes of Streptococcus pneumoniae. This lipoprotein belongs to the ABC-type transport protein complex that transports Mn2+. ABC means ATP binding complex. PsaA is also an adhesion factor that plays a major role in pneumococcal attachment to the host cell and virulence. So, PsaA protein is involved in in colonization of the nasopharyngeal mucosal.
Structure
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This is a test to add a in the Sandbox
Protein-protein interaction
Function
Disease
Meningitis
Otitis
Pneumonia
PsaA protein is an adhesin which is involved in colonization of the nasopharyngeal mucosal. Moreover, alveolar pneumonia is caused by the spread of Streptococcus pneumoniae from nasopharynx. Therefore PsaA protein is involved in infection of pulmonary parenchyma by Streptococcus pneumoniae. Sometimes, Streptococcus pneumoniae pass into the blood and causes a bacteremia besides pneumonia.
Application in Biotechnology
PsaA is being actively evaluated as a component of a vaccin in formulations composed of pneumococcal common proteins. PsaA has been expressed as an E.coli recombinant protein, purified, and evaluated in a phase one clinical trial.
Proteopedia Page Contributors and Editors (what is this?)
Julie Langlois, Atena Farhangian, Rebecca Holstein, Elizabeth A. Dunlap, Katherine Reynolds, Elizeu Santos, Noam Gonen, Anna Lohning, Idan Ben-Nachum, Brian Ochoa, Shai Biran, Gauri Misra, Shira Weingarten-Gabbay, Keni Vidilaseris, Jamie Costa, Abhinav Mittal, Urs Leisinger, Madison Walberry, Edmond R Atalla, Brett M. Thumm, Brooke Fenn, Joel L. Sussman, Mati Cohen, Vesta Nwankwo, Dotan Shaniv, Gulalai Shah
