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2jgy

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[[Image:2jgy.gif|left|200px]]
 
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{{Structure
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==The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate synthetase (UMPS)==
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|PDB= 2jgy |SIZE=350|CAPTION= <scene name='initialview01'>2jgy</scene>, resolution 1.95&Aring;
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<StructureSection load='2jgy' size='340' side='right' caption='[[2jgy]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2jgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGY FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgy OCA], [http://pdbe.org/2jgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgy RCSB], [http://www.ebi.ac.uk/pdbsum/2jgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgy ProSAT]</span></td></tr>
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}}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgy ConSurf].
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<div style="clear:both"></div>
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'''THE CRYSTAL STRUCTURE OF HUMAN OROTIDINE-5'-DECARBOXYLASE DOMAIN OF HUMAN URIDINE MONOPHOSPHATE SYNTHETASE (UMPS)'''
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==See Also==
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
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__TOC__
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==Disease==
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</StructureSection>
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Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
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[[Category: Human]]
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==About this Structure==
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2JGY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGY OCA].
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[[Category: Homo sapiens]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Single protein]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Berg, S van den]]
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[[Category: Berg, S Van Den.]]
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[[Category: Berglund, H]]
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[[Category: Berglund, H.]]
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[[Category: Busam, R]]
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[[Category: Busam, R.]]
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[[Category: Collins, R]]
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[[Category: Collins, R.]]
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[[Category: Dahlgren, L G]]
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[[Category: Dahlgren, L G.]]
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[[Category: Edwards, A]]
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[[Category: Edwards, A.]]
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[[Category: Ericsson, U B]]
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[[Category: Ericsson, U B.]]
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[[Category: Flodin, S]]
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[[Category: Flodin, S.]]
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[[Category: Flores, A]]
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[[Category: Flores, A.]]
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[[Category: Graslund, S]]
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[[Category: Graslund, S.]]
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[[Category: Hallberg, B M]]
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[[Category: Hallberg, B M.]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Holmberg-Schiavone, L]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Johansson, I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg, T]]
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[[Category: Karlberg, T.]]
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[[Category: Kosinska, U]]
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[[Category: Kosinska, U.]]
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[[Category: Kotenyova, T]]
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[[Category: Kotenyova, T.]]
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[[Category: Lehtio, L]]
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[[Category: Lehtio, L.]]
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[[Category: Moche, M]]
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[[Category: Moche, M.]]
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[[Category: Nilsson, M E]]
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[[Category: Nilsson, M E.]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman, T]]
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[[Category: Nyman, T.]]
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[[Category: Ogg, D]]
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[[Category: Ogg, D.]]
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[[Category: Persson, C]]
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[[Category: Persson, C.]]
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[[Category: Structural genomic]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark, J]]
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[[Category: Stenmark, P.]]
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[[Category: Stenmark, P]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell, A G]]
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[[Category: Uppenberg, J.]]
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[[Category: Uppenberg, J]]
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[[Category: Upsten, M.]]
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[[Category: Upsten, M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: alternative splicing]]
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[[Category: Decarboxylase]]
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[[Category: decarboxylase]]
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[[Category: Disease mutation]]
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[[Category: disease mutation]]
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[[Category: Glycosyltransferase]]
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[[Category: glycosyltransferase]]
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[[Category: Lyase]]
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[[Category: lyase]]
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[[Category: Multifunctional enzyme]]
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[[Category: multifunctional enzyme]]
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[[Category: Orotidine-5'-decarboxylase]]
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[[Category: orotidine-5'-decarboxylase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: polymorphism]]
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[[Category: Tim barrel dimer]]
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[[Category: pyrimidine biosynthesis]]
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[[Category: Transferase]]
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[[Category: tim barrel dimer]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:47 2008''
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Current revision

The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate synthetase (UMPS)

2jgy, resolution 1.95Å

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